PPAT Back

phosphoribosyl pyrophosphate amidotransferase

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NCBI Description of PPAT
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPAT is highly significantly mutated in
(none)
PPAT is significantly mutated in
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PPAT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPAT