PPAP2B Back

phosphatidic acid phosphatase type 2B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPAP2B
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells.

Community Annotation of PPAP2B Add / Edit PPAP2B: Annotations

No community annotations yet for PPAP2B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPAP2B is highly significantly mutated in
(none)
PPAP2B is significantly mutated in
(none)
PPAP2B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPAP2B