PPA1 Back

pyrophosphatase (inorganic) 1

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NCBI Description of PPA1

The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PPA1 is highly significantly mutated in
PPA1 is significantly mutated in
PPA1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PPA1