POLR3B Back

polymerase (RNA) III (DNA directed) polypeptide B

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NCBI Description of POLR3B
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

POLR3B is highly significantly mutated in
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POLR3B is significantly mutated in
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POLR3B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for POLR3B