polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

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NCBI Description of POLR2L

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.

Community Annotation of POLR2L Add / Edit POLR2L: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


POLR2L is highly significantly mutated in
POLR2L is significantly mutated in
POLR2L is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for POLR2L