POLR2I Back

polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

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NCBI Description of POLR2I

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

POLR2I is highly significantly mutated in
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POLR2I is significantly mutated in
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POLR2I is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for POLR2I