POLG2 Back

polymerase (DNA directed), gamma 2, accessory subunit

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NCBI Description of POLG2
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

POLG2 is highly significantly mutated in
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POLG2 is significantly mutated in
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POLG2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for POLG2