POLE4 Back

polymerase (DNA-directed), epsilon 4 (p12 subunit)

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NCBI Description of POLE4

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004].

Community Annotation of POLE4 Add / Edit POLE4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


POLE4 is highly significantly mutated in
POLE4 is significantly mutated in
POLE4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for POLE4