POLD1 Back

polymerase (DNA directed), delta 1, catalytic subunit 125kDa

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NCBI Description of POLD1
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

POLD1 is highly significantly mutated in
(none)
POLD1 is significantly mutated in
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POLD1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for POLD1