polymerase (DNA directed), beta

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NCBI Description of POLB

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.

Community Annotation of POLB Add / Edit POLB: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


POLB is highly significantly mutated in
POLB is significantly mutated in
POLB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for POLB