POFUT1 Back

protein O-fucosyltransferase 1

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NCBI Description of POFUT1
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Community Annotation of POFUT1 Add / Edit POFUT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

POFUT1 is highly significantly mutated in
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POFUT1 is significantly mutated in
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POFUT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for POFUT1