patatin-like phospholipase domain containing 8

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NCBI Description of PNPLA8

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PNPLA8 is highly significantly mutated in
PNPLA8 is significantly mutated in
PNPLA8 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PNPLA8