PNMT Back

phenylethanolamine N-methyltransferase

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NCBI Description of PNMT
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of PNMT Add / Edit PNMT: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PNMT is highly significantly mutated in
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PNMT is significantly mutated in
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PNMT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PNMT