PMEPA1 Back

prostate transmembrane protein, androgen induced 1

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NCBI Description of PMEPA1
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of PMEPA1 Add / Edit PMEPA1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PMEPA1 is highly significantly mutated in
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PMEPA1 is significantly mutated in
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PMEPA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PMEPA1