PLK4 Back

polo-like kinase 4 (Drosophila)

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NCBI Description of PLK4
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLK4 is highly significantly mutated in
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PLK4 is significantly mutated in
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PLK4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLK4