PLIN3 Back

perilipin 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PLIN3
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PLIN3 Add / Edit PLIN3: Annotations

No community annotations yet for PLIN3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLIN3 is highly significantly mutated in
(none)
PLIN3 is significantly mutated in
(none)
PLIN3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLIN3