PLIN1 Back

perilipin 1

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NCBI Description of PLIN1
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.

Community Annotation of PLIN1 Add / Edit PLIN1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLIN1 is highly significantly mutated in
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PLIN1 is significantly mutated in
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PLIN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLIN1