PLCD4 Back

phospholipase C, delta 4

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NCBI Description of PLCD4

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.

Community Annotation of PLCD4 Add / Edit PLCD4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PLCD4 is highly significantly mutated in
PLCD4 is significantly mutated in
PLCD4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PLCD4