PLCD1 Back

phospholipase C, delta 1

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NCBI Description of PLCD1
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of PLCD1 Add / Edit PLCD1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLCD1 is highly significantly mutated in
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PLCD1 is significantly mutated in
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PLCD1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLCD1