PLCB3 Back

phospholipase C, beta 3 (phosphatidylinositol-specific)

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NCBI Description of PLCB3

This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PLCB3 is highly significantly mutated in
PLCB3 is significantly mutated in
PLCB3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PLCB3