PLCB1 Back

phospholipase C, beta 1 (phosphoinositide-specific)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PLCB1

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PLCB1 Add / Edit PLCB1: Annotations

No community annotations yet for PLCB1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PLCB1 is highly significantly mutated in
PLCB1 is significantly mutated in
PLCB1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PLCB1