PLCB1 Back

phospholipase C, beta 1 (phosphoinositide-specific)

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NCBI Description of PLCB1
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLCB1 is highly significantly mutated in
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PLCB1 is significantly mutated in
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PLCB1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLCB1