PLAG1 Back

pleiomorphic adenoma gene 1

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NCBI Description of PLAG1
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of PLAG1 Add / Edit PLAG1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLAG1 is highly significantly mutated in
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PLAG1 is significantly mutated in
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PLAG1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLAG1