PLA2G1B Back

phospholipase A2, group IB (pancreas)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PLA2G1B
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008].

Community Annotation of PLA2G1B Add / Edit PLA2G1B: Annotations

No community annotations yet for PLA2G1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PLA2G1B is highly significantly mutated in
(none)
PLA2G1B is significantly mutated in
(none)
PLA2G1B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PLA2G1B