PKNOX2 Back

PBX/knotted 1 homeobox 2

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NCBI Description of PKNOX2
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PKNOX2 is highly significantly mutated in
(none)
PKNOX2 is significantly mutated in
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PKNOX2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PKNOX2