PKMYT1 Back

protein kinase, membrane associated tyrosine/threonine 1

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NCBI Description of PKMYT1
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PKMYT1 is highly significantly mutated in
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PKMYT1 is significantly mutated in
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PKMYT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PKMYT1