PKD2L1 Back

polycystic kidney disease 2-like 1

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NCBI Description of PKD2L1

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PKD2L1 is highly significantly mutated in
PKD2L1 is significantly mutated in
PKD2L1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PKD2L1