PITX3 Back

paired-like homeodomain 3

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NCBI Description of PITX3
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PITX3 is highly significantly mutated in
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PITX3 is significantly mutated in
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PITX3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PITX3