PIP4K2B Back

phosphatidylinositol-5-phosphate 4-kinase, type II, beta

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NCBI Description of PIP4K2B

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIP4K2B is highly significantly mutated in
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PIP4K2B is significantly mutated in
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PIP4K2B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PIP4K2B