PIK3CB Back

phosphoinositide-3-kinase, catalytic, beta polypeptide

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NCBI Description of PIK3CB
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIK3CB is highly significantly mutated in
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PIK3CB is significantly mutated in
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PIK3CB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PIK3CB