PIK3C2B Back

phosphoinositide-3-kinase, class 2, beta polypeptide

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PIK3C2B

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Community Annotation of PIK3C2B Add / Edit PIK3C2B: Annotations

No community annotations yet for PIK3C2B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIK3C2B is highly significantly mutated in
(none)
PIK3C2B is significantly mutated in
(none)
PIK3C2B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PIK3C2B