polymeric immunoglobulin receptor

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NCBI Description of PIGR

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.

Community Annotation of PIGR Add / Edit PIGR: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PIGR is highly significantly mutated in
PIGR is significantly mutated in
PIGR is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PIGR