PIGN Back

phosphatidylinositol glycan anchor biosynthesis, class N

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NCBI Description of PIGN
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported.

Community Annotation of PIGN Add / Edit PIGN: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIGN is highly significantly mutated in
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PIGN is significantly mutated in
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PIGN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PIGN