PIGF Back

phosphatidylinositol glycan anchor biosynthesis, class F

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NCBI Description of PIGF
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of PIGF Add / Edit PIGF: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIGF is highly significantly mutated in
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PIGF is significantly mutated in
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PIGF is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PIGF