PIGB Back

phosphatidylinositol glycan anchor biosynthesis, class B

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NCBI Description of PIGB

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIGB is highly significantly mutated in
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PIGB is significantly mutated in
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PIGB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PIGB