PIF1 Back

PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)

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NCBI Description of PIF1

PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT; MIM 187270), a reverse transcriptase that maintains telomere length (Zhang et al., 2006 [PubMed 16522649]).[supplied by OMIM, Mar 2008].

Community Annotation of PIF1 Add / Edit PIF1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PIF1 is highly significantly mutated in
PIF1 is significantly mutated in
PIF1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PIF1