PIAS1 Back

protein inhibitor of activated STAT, 1

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NCBI Description of PIAS1
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Community Annotation of PIAS1 Add / Edit PIAS1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PIAS1 is highly significantly mutated in
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PIAS1 is significantly mutated in
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PIAS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PIAS1