PI4KA Back

phosphatidylinositol 4-kinase, catalytic, alpha

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NCBI Description of PI4KA

This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PI4KA is highly significantly mutated in
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PI4KA is significantly mutated in
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PI4KA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PI4KA