PH domain and leucine rich repeat protein phosphatase 1

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NCBI Description of PHLPP1

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. CCDS Note: The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data and publications. There are no publicly available human transcripts that include the extended region. However, the update is supported by homologous transcript data and is consistent with the full-length 190 kDa human isoform described in the literature. This 190 kDa product, known as PHLPP1beta, has been detected in several studies, including PMIDs 17386267, 19079341, 20089132, 20819118 and 20861921.

Community Annotation of PHLPP1 Add / Edit PHLPP1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PHLPP1 is highly significantly mutated in
PHLPP1 is significantly mutated in
PHLPP1 is near significance in

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Data details

Mutation list for PHLPP1