PHLDA2 Back

pleckstrin homology-like domain, family A, member 2

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NCBI Description of PHLDA2

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PHLDA2 is highly significantly mutated in
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PHLDA2 is significantly mutated in
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PHLDA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PHLDA2