phosphatase and actin regulator 3

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NCBI Description of PHACTR3

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PHACTR3 is highly significantly mutated in
PHACTR3 is significantly mutated in
PHACTR3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PHACTR3