PGGT1B Back

protein geranylgeranyltransferase type I, beta subunit

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PGGT1B

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of PGGT1B Add / Edit PGGT1B: Annotations

No community annotations yet for PGGT1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PGGT1B is highly significantly mutated in
(none)
PGGT1B is significantly mutated in
(none)
PGGT1B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PGGT1B