PFN2 Back

profilin 2

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NCBI Description of PFN2

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

Community Annotation of PFN2 Add / Edit PFN2: Annotations

No community annotations yet for PFN2.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PFN2 is highly significantly mutated in
PFN2 is significantly mutated in
PFN2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PFN2