PFKFB1 Back

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PFKFB1
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Community Annotation of PFKFB1 Add / Edit PFKFB1: Annotations

No community annotations yet for PFKFB1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PFKFB1 is highly significantly mutated in
(none)
PFKFB1 is significantly mutated in
(none)
PFKFB1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PFKFB1