PFAS Back

phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)

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NCBI Description of PFAS
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PFAS is highly significantly mutated in
(none)
PFAS is significantly mutated in
(none)
PFAS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PFAS