PF4 Back

platelet factor 4 (chemokine (C-X-C motif) ligand 4)

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NCBI Description of PF4
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of PF4 Add / Edit PF4: Annotations

No community annotations yet for PF4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PF4 is highly significantly mutated in
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PF4 is significantly mutated in
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PF4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PF4