PEX14 Back

peroxisomal biogenesis factor 14

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NCBI Description of PEX14
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.

Community Annotation of PEX14 Add / Edit PEX14: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PEX14 is highly significantly mutated in
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PEX14 is significantly mutated in
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PEX14 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PEX14