PEA15 Back

phosphoprotein enriched in astrocytes 15

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NCBI Description of PEA15
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Community Annotation of PEA15 Add / Edit PEA15: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PEA15 is highly significantly mutated in
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PEA15 is significantly mutated in
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PEA15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PEA15