PDLIM2 Back

PDZ and LIM domain 2 (mystique)

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NCBI Description of PDLIM2

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of PDLIM2 Add / Edit PDLIM2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDLIM2 is highly significantly mutated in
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PDLIM2 is significantly mutated in
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PDLIM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PDLIM2