PDK4 Back

pyruvate dehydrogenase kinase, isozyme 4

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NCBI Description of PDK4

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PDK4 is highly significantly mutated in
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PDK4 is significantly mutated in
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PDK4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PDK4