PDK1 Back

pyruvate dehydrogenase kinase, isozyme 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PDK1

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Community Annotation of PDK1 Add / Edit PDK1: Annotations

No community annotations yet for PDK1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PDK1 is highly significantly mutated in
PDK1 is significantly mutated in
PDK1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PDK1